Department of Anesthesia
Ghent University Hospital





Projects govered by RUGLOOP at the Department of Anesthesia, Ghent University, Gent, Belgium
1) Pharmacological research

- 	Pharmacokinetics and dynamics of AQUAVAN™ Injection, a Water-Soluble Prodrug 
	of Propofol as a Bolus Injection : A Phase I Dose Escalation Comparison with 
	DIPRIVAN©

- 	Pharmacodynamic properties of inhaled anesthetics during anesthesia in morbidly 
	obesitas.

-	Pharmacokinetic/dynamic controlled administration of opiates during anesthesia in   
	morbidly obesitas.

-	Onset dynamics of inhaled anesthetics during induction of anesthesia.

-	Optimization of intravenous drug administration in out-OR anesthesia procedures

-	Closed-loop control of hypnotics by model-based controllers and BIS.

2) Physiologicial research : 

-	One lung ventilation during anesthesia

-	Physiological changes during intracranial ventriculoscopic procedures

3) Medical equipment testing and validation : 

-	Accuracy of bispectral index (BIS), mid-latency auditory evoked potentials (MLAEP-
	AAI) and spectral entropy (SE and RE) to measure depth of anesthesia

-	Safety of different sodalimes during low flow anesthesia. (Compound A and CO 
	toxicity)

-	Influence of anesthesia ventilator design on the pharmacological characteristics of inhaled 
         
-	Accuracy of various syringe pumps when controlled by external computer software. 
    (Lab validation of flow accuracy)

-	Comparison of the accuracy of various airway devices during anesthesia.